[]Title:?Characterization of striatal dopamine projections across striatal subregions in behavioral flexibility
[]Journal/Year: Eur J Neurosci. ?(2023)?
[]DOI:?10.1111/ejn.15910
[]Key Findings: by training mice to learn a lever-pressing self-stimulation instrumental task, activating the dopaminergic axons in dorsomedial, dorsolateral, and ventral striatum facilitated, impaired and partially impaired reversal learning, respectively.?
[]Conclusion: the DA release in the dorsomedial striatum is vital for goal-directed behavior, while its release in dorsolateral striatum goes against goal-directed behavior.
[]Comments: 就結論本身而言，本研究毫無新意，屬于用一種新系統去重復一個已知的結論。就實驗結果本身而言，也存在諸多矛盾不可解的地方。很多時候，對于搞科研的人而言，就是需要有定力去看很多可能毫無價值的論文。如果沒有這份定力，始終只追蹤頂尖雜志的論文，也是很難獲得具有較高新意的想法的。所以，這里面存在一個悖論：即要想挖掘出別人沒有覺察到的寶貝，你就得去翻看很多沒人看甚至“沒有價值”的材料。所謂“深入淺出”，便是這個道理。一個人學問的功力或許就隱藏在ta讀過多少其他人沒有讀過或者不愿去讀的材料？
